The explosion occurred at a mosque in Wuro-Burode near yan Gwajo part of Mini.
The blast occurred Tuesday afternoon while worshippers were holding Zuhr (Afternoon ) prayer.
While details of the blast are still sketchy, residents and local officials fear many worshippers were killed.
Head of National Emergency Management Agency (NEMA), Yola operation, Abbani Imam Garki confirmed the blast to newsmen in Yola.
He, however, promised to disclose details of the blast and suspects responsible for the attack.